Abnormal tumor cell energy metabolism can be linked to disturbances in structure and function of the mitochondria. When viewed as a mitochondrial metabolic disease, cancer growth and progression can be managed following a whole body transition from fermentable metabolites, primarily glucose and glutamine, to respiratory metabolites, primarily ketone bodies. This concept forms the basis of using a ketogenic diet for control or prevention of cancer. Since each individual has unique metabolic strengths and weaknesses, metabolic and nutritional therapy will require fine-tuning to match the therapy to each person’s unique physiology.
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